How does the RTRI compare to the HIV-1 LAg-Avidity EIA?
Both RTRIs are based on the same principle of using limiting antigen to distinguish recent or long-term infections (LT line) and use the same antigen as LAg-Avidity EIA but in a rapid lateral low format. The performance of the test in distinguishing recent or long-term infection is similar to the LAg assay at normalized optical density (ODn) cutoff of 2.0 corresponding to mean duration of recent infection (MDRI) of 6 months,.
Parekh B, Detorio M, Shanmugam V, Yufenyuy E, Dobbs T, Kim A, Nkengasong J. Performance evaluation of Asante Rapid Recency Assay for HIV diagnosis and detection of recent infection: potential for surveillance and prevention. Poster session presented at: IAS Conference on HIV Science; 2017 July 23-26; Paris, France. Available at: http://www.ias2017.org/Portals/1/Files/IAS2017_LO.compressed.pdf
Agyemang E., et al. Performance of a novel point-of-care HIV recency test among newly diagnosed pregnant adolescent girls and young women — Malawi, 2017. International AIDS Conference 2018 abstract number THPEC 200, 2018